Genetic variants associated with a person’s blood type may be linked to their risk of early stroke, according to a new meta-analysis.
Genetic variants associated with a person’s blood type may be linked to their risk of stroke before age 60, according to a new meta-analysis. The study included all available data from genetic studies including ischemic stroke in young adults, which is caused by a blockage of blood flow to the brain. The meta-analysis was recently published in Neurologythe medical journal of the American Academy of Neurology.
“Non-O blood types have been previously associated with risk of early stroke, but the results of our meta-analysis showed a stronger link between these blood groups with early stroke compared to late stroke, and by linking risk primarily to blood type A,” said study author Braxton D. Mitchell, PhD, MPH, of the University of Maryland School of Medicine in Baltimore. “Specifically, our meta-analysis suggests that genetic variants linked to blood groups A and O account for almost all those genetically linked to early stroke.People with these genetic variants may be more likely to develop blood clots, which can lead to stroke.
48 studies on genetics and ischemic stroke from North America, Europe and Asia were reviewed in the meta-analysis. 16,927 people with stroke and 576,353 people without stroke were included in the studies. Of those who had a stroke, 5,825 people had an early stroke and 9,269 people had a late stroke. Early-onset stroke was defined as ischemic stroke occurring before age 60 and late-onset stroke was over age 60.
In order to identify genetic variants associated with stroke, scientists examined all chromosomes. They found a link between early stroke and the area of the chromosome that includes the gene that determines blood type A, AB, B or O.
After dividing the participants into blood groups A, AB, B, and O. they recompiled the data and compared the prevalence of these blood groups in people with early stroke, late stroke, and people without stroke. stroke.
In the analysis, the researchers found that people with early stroke were more likely to have blood type A and less likely to have blood type O compared to people with late stroke and people without. Stroke. Compared to controls, both early and late strokes were also more likely to have blood type B.
Next, they focused on people of European ancestry, comparing 5,825 people with early stroke to 29,320 people without stroke. There, the meta-analysis found that 48% of people with early stroke had blood type A, compared to 45% of people with late stroke and 44% of people without stroke. They also calculated that 35% of people with early stroke had blood type O, compared to 39% of those with late stroke and 41% of people without stroke.
After adjusting for various factors, including gender, scientists found that people with blood type A had a 16% higher risk of having an early stroke than people with other blood types. On the other hand, those with blood type O had a 12% lower risk of having a stroke than people with other blood types.
“This work deepens our understanding of the development and early changes of stroke,” said Jennifer Juhl Majersik, MD, MS, of the University of Utah and fellow of the American Academy of Neurology, who authored a editorial accompanying the study. “Future research is needed to help develop a more accurate understanding of how stroke develops. This could lead to targeted preventative treatments for early strokes, which could lead to less disability during people’s most productive years.
Although 35% of the participants were of non-European ancestry, a limitation of the study was the lack of diversity among the participants.
To learn more about this research, see Blood type can predict your risk of having a stroke before age 60.
Reference: “Contribution of common genetic variants to the risk of early ischemic stroke” by Thomas Jaworek, Huichun Xu, Brady J Gaynor, John W. Cole, Kristiina Rannikmae, Tara M Stanne, Liisa Tomppo, Vida Abedi, Philippe Amouyel, Nicole D Armstrong, John Attia, Steven Bell, Oscar R Benavente, Giorgio B Boncoraglio, Adam Butterworth, for the Cervical Artery Dissections and Ischemic Stroke Patients (CADSIP) consortium, Jara Carcel-Marquez, Zhengming Chen, Michael Chong, Carlos Cruchaga, Mary Cushman, John Danesh, Stephanie Debette, David J Duggan, Jon Peter Durda, Gunnar Engstrom, Chris Enzinger, Jessica D Faul, Natalie S Fecteau, Israel Fernandez-Cadenas, Christian Gieger, Anne-Katrin Giese, Raji P Grewal, Ulrike Grittner, Aki S Havulinna, Laura Heitsch, Marc C Hochberg, Elizabeth Holliday, Jie Hu, Andreea Ilinca, for the INVENT Consortium, Marguerite R Irvin, Rebecca D Jackson, Mina A. Jacob, Raquel Rabion and Janssen, Jordi Jimenez-Conde, Julie A Johnson, Yoichiro Kamatani, Shar on L. Kardia, Masaru Koido, Michiaki Kubo, Leslie Lange, Jin-Moo Lee, Robin Lemmens, Christopher R Levi, Jiang Li, Liming Li, Kuang Lin, Haley Lopez, Sothear Luke, Jane Maguire, Patrick F McArdle, Caitrin W .McDonough, James F Meschia, Tiina Metso, Martina Muller-Nurasyid, Timothy D O’Connor, Martin O’Donnell, Leema R Peddareddygari, Joanna Pera, James A Perry, Annette Peters, Jukka Putaala, Debashree Ray, Kathryn Rexrode, Marta Ribases, Jonathan Rosand, Peter M Rothwell, Tatjana Rundek, Kathleen A Ryan, Ralph L. Sacco, Veikko Salomaa, Cristina Sanchez-Mora, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Jennifer A Smith, Nicholas L Smith, Sylvia Wassertheil-Smoller , Martin Soederholm, O. C Stine, Daniel Strbian, Cathie L Sudlow, Turgut Tatlisumak, Chikashi Terao, Vincent Thijs, Nuria P Torres-Aguila, David-Alexandre Tregouet, Anil M. Tuladhar, Jan H Veldink, Robin G Walters, David R Weir, Daniel Woo, Bradford B Worrall, Charles C Hong, Owen Ross, Ramin Zand, Frank-Erik de Leeuw, Arne G Lindgren, Guillaume Pare, Christopher D. Anderson, Hugh S Markus, Christina Jern, Rainer Malik, Martin Dichgans, Braxton D Mitchell, Steven J Kittner, Early Onset Stroke Genetics Consortium of the International Stroke Genetics Consortium (ISGC), August 31 2022 , Neurology.
DOI: 10.1212/WNL.0000000000201006
The study was supported by the National Institutes of Health and the Department of Veterans Affairs.
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